https://www.cbsnews.com/

First published on August 29, 2019

Is there a "gay gene"? Major new study says no

By Dennis Thompson

There's no such thing as a single "gay gene" that drives a person's sexual behavior, concludes the largest genetic study ever conducted on the issue. Instead, a person's attraction to those of the same sex is shaped by a complex mix of genetic and environmental influences, similar to what's seen in most other human traits, researchers report.

"This is a natural and normal part of variation in our species," said researcher Ben Neale, director of genetics with the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard. "That should also support the position that we shouldn't try and develop gay cures. That's not in anyone's interest."

The international study focused on the genetic profiles of nearly 480,000 people from the United States and the United Kingdom, a group approximately 100 times larger than any previous study of the link between genetics and same-sex attraction, said lead researcher Andrea Ganna, a research fellow with the Massachusetts General Hospital's Analytical and Translational Genetic Unit.

The research team discovered five specific genetic variants that were significantly associated with same-sex behavior, but when combined these variants explained less than 1% of any person's attraction to their own gender, Ganna said.

Overall, genetics account for between 8% and 25% of a person's same-sex attraction, taking into account the thousands of genetic traits ultimately involved in shaping a person's sexual desires, Neale said.

"It's effectively impossible to predict an individual's sexual behavior from their genome," Neale said. "Genetics is less than half of this story for sexual behavior, but it's still a very important contributing factor. These findings reinforce the importance of diversity as a key aspect of sexual behavior."

GLAAD, the world's largest LGBTQ advocacy group, said the results show that sexual orientation is just another normal piece of the human experience.

"This new study provides even more evidence that that being gay or lesbian is a natural part of human life, a conclusion that has been drawn by researchers and scientists time and again," said GLAAD Chief Programs Officer Zeke Stokes. "The identities of LGBTQ people are not up for debate. This new research also reconfirms the long-established understanding that there is no conclusive degree to which nature or nurture influence how a gay or lesbian person behaves."

The results also call into question the Kinsey Scale, a long-utilized rating scale of sexual attraction developed in part by sex researcher Alfred Kinsey, Ganna said.

"We discovered that the Kinsey Scale, which really places individuals on a continuum from basically exclusively opposite-sex partners to exclusively same-sex partners, is really an oversimplification of the diversity of sexual behavior in humans," Ganna said.

"That can't be a single line," Neale added. "The results are not consistent with that being a single line, but they don't actually tell us what those other dimensions are" that shape human desire.

Researchers are now considering whether a person's attraction to men and to women should be considered separate from each other, with the two characteristics shaping the person's overall sexual identity and desires, Ganna said.

The findings were published Aug. 29 in the journal Science.

The results did show that genetic variation has a stronger influence on same-sex sexual behavior in men than in women, possibly demonstrating the complexity of women's sexuality, said Melinda Mills, a professor of sociology at Oxford University who wrote an editorial accompanying the new study.

"This reflects voices from the LGBTQ+ (lesbian, gay, bisexual, transgender, queer+) community arguing that a range of sexualities exist," Mills wrote. "Sexuality is dynamic, with the ability to express and realize sexual preferences, and is thus also shaped and regulated by cultural, political, social, legal and religious structures."

The five specific genes related to same-sex desire cropped up in odd places, the researchers noted.

For example, one was located in a stretch of DNA that contains several genes related to the sense of smell, Ganna said.

"We know that smell has a strong tie to sexual attraction, but its links to sexual behaviors are not clear," he said.

Another gene was associated with male baldness, which is closely linked to how the body regulates sex hormones and might suggest a relationship between hormone regulation and same-sex desire, Ganna said.

Despite their overall small effect, "these genetic variants could hint at some biological pathways that may be involved in same-sex sexual behavior," Ganna said.

Redazione ANSA  

30 agosto 2019

Non esiste un gene dell'omosessualità, mix Dna e ambiente 

La ricerca pubblicata su Science su mezzo milione di persone coordinata da un italiano

Non esiste il gene dell'omosessualità. Il comportamento sessuale è infatti determinato da un complesso mix di fattori genetici e ambientali, con migliaia di geni che danno un contributo limitato rispetto all'influenza esercitata dall'ambiente e dalla cultura. Lo dimostra su Science il più ampio studio genetico sul tema, condotto su mezzo milione di persone da un consorzio internazionale di ricerca coordinato dall'italiano Andrea Ganna del Broad Institute di Mit e Harvard, negli Stati Uniti.

"Studi precedenti avevano suggerito la presenza di segnali genetici forti che potessero far prevedere il comportamento sessuale: uno dei più noti puntava al cromosoma X, ma nel nostro studio, con un campione 100 volte più grande, abbiamo dimostrato che non è così", racconta Ganna all'ANSA. 

Per affrontare la questione in modo statisticamente rigoroso, i ricercatori hanno esaminato i dati relativi a oltre mezzo milione di persone presenti in due grandi banche dati genetiche: la britannica UK Biobank e la statunitense 23andMe. "Abbiamo fatto uno screening di tutto il genoma, esaminando milioni di marcatori genetici per vedere quali potessero essere associati al comportamento sessuale dichiarato dalle persone nei questionari", continua Ganna.

Sono così emerse cinque varianti genetiche legate in modo statisticamente significativo all'omosessualità, di cui ancora non si conosce bene la funzione: "Sappiamo che una di queste varianti si trova in una regione del Dna che esprime recettori per l'olfatto, mentre un'altra è associata alla calvizie maschile e probabilmente alla regolazione ormonale, ma per ora sono solo ipotesi", spiega il ricercatore, che lavora anche per il Laboratorio Europeo di Biologia Molecolare presso l'Istituto di medicina molecolare finlandese (Fimm-Embl).

"Messe tutte insieme - sottolinea Ganna - le cinque varianti che abbiamo trovato spiegano meno dell'1% della variabilità nel comportamento sessuale. È probabile che esistano migliaia di altri geni legati in qualche modo al comportamento sessuale, anche se stimiamo che potrebbero contribuire al massimo per il 25% a questo tratto molto complesso, che dal punto di vista genetico rientra nella normale variabilità umana".

.